Proteoglycan and Sialic acid

Proteoglycans are more than 95% carbohydrate by weight. Proteoglycan helps to provide us with the idea to the molecule's various chemical compositions. As proteo refers to protein, while glycan represents sugar or a group of sugars, so proteoglycan is a long polysaccharide chain covalently attached to a protein. The protein component of proteoglycans is synthesized by ribosomes and mainly translocated into the lumen of the rough endoplasmic reticulum. Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone and are found widely distributed in animal tissues and to a lesser extent in some other organisms, ranging from fungi,plants,yeasts and bacteria, mostly in glycoproteins and gangliosides.

 

  • Glycosaminoglycans
  • Structure of proteoglycans
  • GAGs and glycolipids
  • Cell - cell adhesion molecules
  • Sialic-acid-binding lectins
  • Synthesis of sialic acids

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