Conference Series LLC Ltd. feels great pleasure to invite you all to attend International Conference on Glycobiology & Glycoproteomics (Glycobiology Conference 2019) is going to be held in Chicago, Illinois, USA in April 17-18, 2019. The conference is going to bring together glycobiologists, scientists, molecular biologists, biochemists, industrial experts, delegates, sponsors and related exhibitors from all around the world to the marvelous city of Chicago, Illinois, USA. The conference theme focuses on " Facts, fictions and future of glycos: A closure look ".
Glycobiology in wider aspects includes the study of structure, function and biology of carbohydrates, biosynthesis related to sugars and saccharides. Recently Glycobiology is fast emerging as a preliminary field of interest for biomedical and bimolecular research around the world. It is the growing field in the area of research related to biomolecules which mainly includes the study of different metabolic pathways, along with the prediction of the various structures of sugar related biomolecules and many others etc.
Why to attend???
Various members from all around the globe have focused their research and expertise on learning more and more about various biomolecules and use of Glycobiology, this is a best chance to meet the global participants in the wider arena of Glycobiology, to share information, meeting with current and expert researchers and receive name recognition in this two day premier event.
Scientists and Researchers
Biochemistry Associations and Societies
Research Training Institutes
Conference Series LLC Ltd. invites all the participants across the globe to attend the 6th International Conference on Glycobiology & Glycoproteomics during April 17-18, 2019 at Chicago, Illinois, USA.
Glycobiology Conference 2019 is designed to meet all renowned and eminent speakers, research experts from all around the globe with delegates, exhibitors, industry experts and work shop symposiums.
For more details: https://glycosummit.biochemistryconferences.com/
It involves the study of everything related to the structure, bio-synthesis, and biology of sugars and saccharides drawing from simple organic chemistry, molecular and cellular biology, enzymology and related domains. Like amino acids and nucleic acids, sugars are the major contributors in nature many natural products contain oligosaccharides that are important for their biological and biochemical activity and carbohydrates have major roles in a wider range of biological processes including signal transduction mechanisms and immune responses. So the study of glycan structures is also complicated by the lack of a proper and direct template for their biosynthesis, contrary to the case with amino acids and proteins.
Glycoscience has become a vital, expanding and important extension of modern molecular biology and biomedicine in today’s era. The wider complexity of glycosylated and related structures is only paralleled to their utility. Discovering carbohydrate and glycan antigens as cancer biomarkers or even abnormal glycation pathways in metabolic disorders such as diabetes inhibited the importance of the expansion of glycoscience in a future, as a way of representing new biomarkers and therapeutic targets in disease. The final goal is to enhance research capabilities on glycosciences and provide ground to present and future emerging discoveries in glycosciences into new clinical applications and diagnostics.
Proteoglycans are more than 95% carbohydrate by weight. Proteoglycan helps to provide us with the idea to the molecule's various chemical compositions. As proteo refers to protein, while glycan represents sugar or a group of sugars, so proteoglycan is a long polysaccharide chain covalently attached to a protein. The protein component of proteoglycans is synthesized by ribosomes and mainly translocated into the lumen of the rough endoplasmic reticulum. Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone and are found widely distributed in animal tissues and to a lesser extent in some other organisms, ranging from fungi,plants,yeasts and bacteria, mostly in glycoproteins and gangliosides.
Glycoproteomics is emerging and booming as an important sub discipline of proteomics, focusing on the role of protein glycosylation in various biological processes. It focusses on branch of proteomics that identifies, summarizes, and characterizes proteins containing carbohydrates as a posttranslational modification by using Mass spectrometry which is commonly and widely used to identify the sugar moieties attached. Glycomics is the comprehensive study of glycomes the entire complement of sugars, whether free or present in more complex molecules of an organism including genetic, pathologic, physiologic, and other aspects. Glycomics "is the systematic study of all glycan structures of a given cell type or organism" and is a subset of glycobiology.
Carbohydrates were very important in the early history of immunology in describing the identity of antigens which are recognized by antibodies. So the ability of these antibodies to uniquely recognize glycans and carbohydrate related molecules was exploited in studies defining the size of the antigen-binding site. Numerous carbohydrate-binding proteins, or lectins, have been identified on the surfaces of immune cells which intensify the importance of carbohydrates in both innate and adaptive immune responses in development of modern vaccines and immunological therapeutics. Recently glycobiologists and immunologists are now collaborating extensively to explore this crucial field in the area of immunobiology.
Glycolipids are limited in fractions but known to be major and important contributors of glycoconjugates in all areas of life. The structural diversity of glycolipids is exceptional, as different types of lipids are glycosylated in almost every forms of life like animals, plants, and bacteria. Their role basically is to maintain stability of the membrane and to facilitate other cellular recognition. They act as glycan-carriers in the membranes of photosynthetic structures in, algae, plants and bacteria.
Glycopeptides are basically peptides that contain carbohydrate moieties generally glycan’s which are covalently attached to the side chains of the amino acid residues that constitute the peptide. These include a class of drugs of microbial origin that are composed of glycosylated cyclic or polycyclic non ribosomal peptides.
Carbohydrates are basically considered as major sources of structural materials and energy for living organisms. Recent modern research’s in this area has focused mainly on simple basic sugars and homopolysaccharides such as, starch, cellulose, glycogen, and chitin. During the last few decades, the researchers have shifted their focus on complex forms like carbohydrates, especially proteoglycans, glycolipids and glycoproteins which are collectively referred to as glycoconjugates that shows the potential of recognition markers in the biological system which also relates to other biomedical and clinical fields.The roles of glycans and glycoconjgates in cancer have been emphasizes, because a small alterations in glycosylation can tremendously regulate the whole pathway and mechanisms of cancer, which leads to an indication as a biomarker development leading to various therapeutics development in cancer research.
Carbohydrate rich molecules like including glycolipids, glycoproteins, and proteoglycans in the nervous system have important roles during development, regeneration and synaptic plasticity. The structural diversity of the carbohydrate moieties renders them ideally suited as stage-specific biomarkers for various cell types leading to mediate interactions between recognition molecules, thereby contributing to the formation of a complex molecular framework at the cell surface and in the extracellular matrix of the cell. The exceptional structural diversity of glycan chains and related moieties allows for immense advanced possibilities that can leads to cell interactions along with cell matrix interactions.
Glycomics parallel to proteomics and genomics is the systematic study of all the glycan structures of a given cell type or organism and is a subset of glycobiology. Sugars are generally linked to other types of biological molecule to form glycoconjugates. The various enzymatic process of glycosylation creates sugars or saccharides linked to themselves and to other molecules by the glycosidic bond, finally producing glycans. Proteoglycans, glycoproteins, and glycolipids are the most abundant glycoconjugates found in mammalian cells. Glycoconjugates have been shown to be important and play prominent role in cell-cell interactions due to the presence on the cell surface of various glycan binding receptors in addition to the glycoconjugates themselves.
Mass spectrometry (MS) is a vital analytical technique that ionizes chemical species and sorts the ions based on their mass-to-charge ratio. A mass spectrum is a plot of the ion signal as a function of the mass-to-charge ratio during experimental analysis. These spectra are then used to determine the elemental or isotopic signature of a sample for observations, the masses of particles and of various molecules, and to clarify the chemical structures of desired molecules, such as biomolecules, glycopeptides and other chemical compounds.
Recent technological advances in the field of glycobiology and glycochemistry are showing the way for a new era in carbohydrate related vaccine design. This is enabling a tremendous efficiency in the synthesis, identification, and evaluation of unique glycan epitopes found on a number of pathogens and cancerous cells. Glycans and related carbohydrate molecules are at the center of many disorders and diseases opening the possibility of exploiting them for therapeutic and diagnostic purposes. There are various biochemical pathways and diseases in which carbohydrates are complexly involved.
Glyco-epitope diversity enhances the role of glycans and is now considered essential for life, both under normal and pathological conditions. The vital role of glycans in the research and development of diseases and the possible therapeutic use of this class of molecules by describing how the interaction of glycans with growth factors, extracellular proteases ,growth factor binding proteins, protease inhibitors, chemokines, morphogens, and adhesive proteins regulates inflammation, infection, atherosclerosis, cancer, thrombosis and embryonic stem cell biology.
Genetic disorder of glycosylations
Growth factors and oncogenes
Genetically engineered glycan
Generally glycans are vital components of many bio therapeutic agents, differing from natural products to molecules based on various rational designs to recombinant glycoproteins and glycoconjugates. The glycan components of these agents can be important determinants of their biological activity and therapeutic efficacy. Modern patenting of new therapeutics typically requires clarifications of the composition of matter in the claimed molecule for approval. Many remarkable advances can be seen in the areas of imaging, structure prediction technologies and advancement of hybrid methods to understand the structure and function of carbohydrates and proteins.
Glycobiology Conference 2019 welcomes attendees, presenters and exhibitors from all over the world to Chicago, Illinois, USA. We are delighted to invite you all to attend and register for the “6th International Conference on Glycobiology & Glycoproteomics which is going to be held during April 17-18, 2019 in Chicago, Illinois, USA.
The organizing committee is gearing up for an exciting and informative conference program including plenary lectures, symposia, workshops on a variety of topics, poster presentations and various programs for participants from all over the world. We invite you to join us at the Glycobiology Conference 2019 where you will be sure to have a meaningful experience with scholars from around the world. All the members of the Glycobiology Conference 2019 organizing committee look forward to meeting you in Chicago, Illinois, USA.
Importance & Scope:
Most aspects of glycobiology depend on successful researches. Glycobiology Conference 2019 aims to bring together leading academic scientists, researchers and research scholars to exchange and share their experiences and research results about all aspects of Glycobiology leading way to the unraveled. It also provides the chance for researchers, practitioners and educators to present and discuss the most recent innovations, trends, and concerns, practical challenges encountered and the solutions adopted in the fields of glycobiology.
Glycobiology Conference 2019 is an essential platform for presenting research about marketing, exchanging ideas about it and thus, contributes to the dissemination of knowledge for the benefit of both the academia and business. Glycobiology is where the future intersects. This event brings together eminent researchers and associates to explore the emerging field. We bring together knowledge, creative, and technology leaders from the biology industry for the most current and relevant discussions.